SUMMARY, EXPLANATION AND LIMITATIONS:
p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. p63 is detected in prostatic basal cells in normal prostate, however, it is negative in malignant tumors of the prostate gland. Thus p63 is a useful differential marker for benign and malignant tumors of prostate gland and can be used in a panel of antibodies such as HMW CK (34ßE12), PSA and PSAP. p63 may play a significant role in prostate development by maintaining a prostate stem cell population. Striated muscle staining may be observed with p63.
Immunogen: Recombinant protein derived from amino acid residues 1-205 of human p63.
Staining pattern: Nuclear.
Positive control: Tissue sample from prostate, breast, skin, prostate carcinoma or squamous cell carcinoma.
This antibody is designed for the specific localization of human p63 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.