SUMMARY, EXPLANATION AND LIMITATIONS:
MUM1 or IRF-4 (Multiple Myeloma oncogene 1 or Interferon regulatory factor-4) belongs to the IRF family of factors that bind to DNA which regulate both the interferon and the interferon-induced genes. MUM1 is also known as LSIRF (Lymphocyte Specific Interferon Regulatory Factor) and is a specific nuclear protein of lymphoid cells and acts as a transcriptional activator that binds to DNA sequences in the promoter ISRE (Interferon Stimulated Response Element) MHC class I. MUM1/IRF4 is a myeloma associated oncogene is activated by chromosomal translocation t (6; 14) (p25, q32. When not expressed does not occur B/T cell activation or immunoglobulin secretion by plasma cells . Most neoplasms composed by mature lymphoid cells expressing MUM1.
Immunogen: Recombinant human IRF-4 protein.
Staining pattern: Nuclear and weakly cytoplasmic.
Positive control: Tissue sample from tonsil or lymph node.
This antibody is designed for the specific localization of human MUM1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
MUM-1 Is a marker usefull to characterize the histiogenesis of B origen lymphomas/leukemias. In non-Hodgkin lymphoma B, expression of MUM-1 was observed in 73.2% of lymphomas diffuse large cell B in 20% of lymphomas as marginal and 43% of cell lymphocytic lymphoma small. MUM-1 staining intensity several types of T lymphomas including: leukemia/lymphoma adult T (ATL/L), T cell lymphoma and anaplastic most Hodgkin lymphomas. MUM-1 is not expressed in B lymphoma mantle or germinal center B-cell lymphomas. In the case of the B lymphomas diffuse large cell and the expression of LLC MUM-1 has been shown to have prognostic value. MUM-1 is positive in 92% of primary and metastatic melanomas by what may be included in the panel for differential diagnosis of this tumor to be negative in schwannomas, neurofibromas, and tumors of peripheral nerve sheaths and in desmoplastic melanomas and of spindle cells.