SUMMARY, EXPLANATION AND LIMITATIONS:
Mammaglobin, a 10 kDa glycoprotein of unknown function, can be detected in the majority of primary and metastatic breast carcinomas. According to the current state of knowledge the mammaglobin gene is expressed almost exclusively in normal breast tissue and in breast carcinomas. Known exceptions are eccrine sweat glands of the skin which also express the gene.
Mammaglobin is thought to be a useful marker for characterisation of metastases of breast carcinomas. Studies have shown that in this context mammaglobin is more sensitive and specific than BRST-1 (BSA-225, TAG-90). In comparison with BRST-2 (GCDFP-15) mammaglobin is deemed to be slightly less specific but more sensitive. The determined values for mammaglobin were: 85 % specificity and 84.3 % sensitivity.
Immunogen: Recombinant full length protein Mammaglobin A protein.
Staining pattern: Cytoplasmic or nuclear.
Positive control: Tissue sample from breast carcinoma.
This antibody is designed for the specific localization of human mammaglobin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.