SUMMARY, EXPLANATION AND LIMITATIONS:
Blood consists of a solid component that includes erythrocytes, leukocytes and platelets, and a liquid component known as plasma, which is a buffered solution of proteins and salts. Innate and adaptive immune responses rely on the function of leukocytes, which are nucleated white blood cells that destroy invading cells and remove debris. White blood cells, also designated polymorphonuclear leukocytes, include granulocytes, monocytes and mast cell precursors. Macrophages are tissue-localized, differentiated cells derived from circulating monocytes. Along with circulating neutrophils, macrophages are phagocytic cells that engulf antibody-coated pathogens, which are subsequently degraded in intracellular vesicles. Tissue-localized macrophages can target a spectrum of bacterial pathogens without requiring previous exposure.
Immunogen: Affinity purified monocyte membrane preparation.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from tonsil, lymph node or spleen.
This antibody is designed for the specific localization of human macrophage using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.