SUMMARY, EXPLANATION AND LIMITATIONS:
Lysozyme is a 14.4 kDa enzyme which lyses bacterial cell wall by hydrolyzing its polysaccharide components. It is abundant in several secretions, such as tears. This enzyme is localized in cytoplasmic granules from polymorphonuclear neutrophils. It is abundant in mucosal secretions, and released by them.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human lysozyme using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Anti-lysozyme stains myeloid cells, histiocytes, granulocytes, macrophages and monocytes in human tonsil, colon and skin. It is an important marker which can demonstrate the myeloid or monocytic nature of acute leukemia. This antibody restrictive stain nature suggest that lysozyme can be synthetized predominantly in reactive histiocytes than in repose non stimulated phagocytes. It is not demonstrated that anti-lysozyme stains other cell or tissue type. It can help identifying histiocytic neoplasms and big lymphocytes, as well as classifying lymphoproliferative disorders.