SUMMARY, EXPLANATION AND LIMITATIONS:
Extracellular matrix (ECM) surrounds and separates most tissues compartments, it determinates the tissue structure and the dynamic interaction with neighbor cells. The basement membrane is part of ECM and it is composed by collagens, proteoglycans, elastin, and several glycoproteins, which laminin is the most abundant. Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains Dystroglycan is a major laminin receptor in muscle and epithelia, and nidogen is a high-affinity laminin-binding protein important for basement-membrane assembly.
Immunogen: Laminin isolated from a rat yolk sac tumor cell line.
Staining pattern: Basement membrane.
Positive control: Tissue sample from skin, placenta or kidney.
This antibody is designed for the specific localization of human laminin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.