SUMMARY, EXPLANATION AND LIMITATIONS:
Antibody to the kappa light chain of immunoglobulin is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Immunogen: Kappa light chains purified from human Bence Jones proteins.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human kappa light chain using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Is useful for detecting monoclonality in B cell lymphoproliferative disorders, which provides significant support diagnosis of lymphoma versus lymphoid hyperplasia or other reactive lymphadenitis; as well as in leukemia and plasma cell, plasma cell dysplasias myelomas or plasmacytomas.