SUMMARY, EXPLANATION AND LIMITATIONS:
Herpes simplex virus I and II (HSV-I and HSV-II) are two strains of the Herpes virus family, Herpesviridae, which cause infections in humans. After an initial, or primary, infection, HSV establishes latency, during which the virus is present in the cell bodies of nerves which innervate the area of original outbreak. Herpes symptoms may periodically recur in the form of outbreaks of herpetic sores near the site of original infection. HSV-I usually infects the non-genital mucosal surfaces, and HSV-II typically involves the genitalia. Either type may affect the skin or internal organs (typically brain, lung, liver, adrenal gland, or GI tract) of immunocompromised individuals. This antibody reacts with HSV-I and HSV-II Herpes viruses. There may be cross-reactivity with varicella zoster virus at higher concentrations. Cross-reactivity with CMV or Epstein-Barr virus is not seen with this antibody.
Staining pattern: Nuclear and cytoplasmic.
Positive control: Tissue sample from any tissue infected with HSV 1 & 2.
This antibody is designed for the specific localization of human HSV 1 & 2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.