SUMMARY, EXPLANATION AND LIMITATIONS:
The human herpes virus type 8 (HHV-8) is probably the cause for Kaposi’s sarcoma. DNA-sequences of HHV-8 were found in Kaposi’s sarcoma lesions, primary effusion lymphomas and in multicentric Castleman’s disease. Polymerase chain reaction and in situ hybridisation were used for these studies. This anti-HHV-8 antibody labels the latent nuclear antigen protein via immunohistochemistry. The latent nuclear antigen protein of HHV-8 (LNA, LNA-1, LANA-1), encoded by viral gene ORF73, is a nuclear antigen which is constantly expressed in all cells latently infected by the virus. It has a molecular weight of 222 or 234 kDa. The detection of HHV-8 via immunohistochemistry can be helpful for an interpretation of the results in context of the morphological features.
Immunogen: Recombinant latent nuclear antigen 1 of HHV8.
Staining pattern: Nuclear.
Positive control: Tissue sample from Kaposi’s sarcoma.
This antibody is designed for the specific localization of human HHV8 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.