SUMMARY, EXPLANATION AND LIMITATIONS:
Glypican 3, also known as GPC3, is a human gene. The protein encoded by this gene is a member of the glypican family. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl-phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Immunogen: Peptide of 70 amino acid C-terminal region.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from hepatocellular carcinoma.
This antibody is designed for the specific localization of human glypican-3 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.