SUMMARY, EXPLANATION AND LIMITATIONS:
Glial fibrillary acidic protein (GFAP), is one of the fibrillary proteins which stains the intermediate filaments from the intracellular cytoskeleton, particularly glial cells such as astrocytes and Schwann cells. GFAP was first described in 1971, it is a type III protein codified by a gene, which in humans is located on the 17 chromosome. Its main function is protecting the rigid organization of the intern 3D structure from brain astrocytes, enabling kind of flexibility and curvature. In many cells GFAP is straightly related with vimentin, desmin, and peripherin, which takes part of the structure and function of the cytoskeleton.
Immunogen: Glial Fibrillary Acidic Protein.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from astrocytoma.
This antibody is designed for the specific localization of human GFAP using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
This antibody strains astrocytes, glia cells and ependymal cells, as well as its derived tumors. On the central nervous system it strains satellite cells and enteric glial cells. It has been observed a low strain in axons, it has been attributed to a cross reaction with the neurofilaments.