Ref: AP10048C – Clone: 23A3 – Host: Mouse – Method: P,F – Format: Concentrated

SKU: AP10048C Category: Tag:



Gross Cystic Disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross Cystic Disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15 kDa monomer protein, GCDFP-15. The cells within the body that produce GCDFP-15 appear to be restricted primarily to those with apocrine function such as breast cysts and in apocrine glands in the axilla, vulva, eyelid, and ear canal. Studies have found GCDFP-15 to be a highly specific and sensitive marker for breast cancer. Approximately 70% of breast carcinomas stain positive with antibody to GCDFP-15. In contrast, Colorectal Carcinomas, as well as Mesotheliomas, do not stain with this antibody. Lung Adenocarcinomas rarely stain with this antibody.

Clone: 23A3

Isotype: IgG2a

Immunogen: Recombinant protein encoding the excreted domain of human GCDFP15.

Staining pattern: Cytoplasmic.

Positive control: Tissue sample from breast or skin.


This antibody is designed for the specific localization of human GCDFP-15 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

Some studies have reported that GCDFP-15 can be a highly specific and sensitive marker for breast cancer. Approximately, 70% of carcinomas are positive for this antibody. In contrast, colonrectales carcinomas, mesotheliomas, are negative for this antibody. Lung adenocarcinomas rarely stain with this antibody. GCDFP-15 and PSA were co-expressed in breast cancers positive for androgen receptor.