SUMMARY, EXPLANATION AND LIMITATIONS: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
This antibody reacts with human fibronectin in liver, tonsil, skin, and kidney. Traces of contaminating antibodies have been removed by immunospecific purification. This antibody shows no reaction with Collagen IV, laminin, vitronectin and chondroitin sulfate type A, B and C. The product cross-reacts with bovine, chicken, goat, guinea pig, mouse, pig, rat and sheep fibronectin.
Immunogen: Purified human fibronectin.
Staining pattern: Basement membrane and connective tissue.
Positive control: Tissue sample from kidney.
This antibody is designed for the specific localization of human fibronectin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.