SUMMARY, EXPLANATION AND LIMITATIONS:
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2,-3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Immunogen: Extracellular domain of human recombinant EGFR protein.
Staining pattern: Cell membrane.
Positive control: Tissue sample from placenta or squamous cell carcinoma.
This antibody is designed for the specific localization of human EGFR using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.