SUMMARY, EXPLANATION AND LIMITATIONS:
Keratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.
Immunogen: Keratin preparation from a human carcinoma.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from breast or colon carcinoma.
This antibody is designed for the specific localization of human cytokeratin 8 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.