SUMMARY, EXPLANATION AND LIMITATIONS:
Cytokeratin 8 (CK8, 52 KDa) and Cytokeratin 18 (CK18, 45kDa) are typical cytokeratins of simple epithela and derived neoplasias. Usually, CK8 and CK18 are co-expressed but there are exceptions both in normal and abnormal tissue.Therefore it could be helpful to stain both cytokeratins separately to determine the keratin expression pattern more precisely. Simple secretory epithelia (both ductal and glandular) are positive for CK18 as well as the majority of adenocarcinomas, basal cell carcinomas and mesotheliomas. Negative for CK18 are stratified epithelia, squamous cell carcinomas, acanthocytes as well as all non-epithelial tumours.
Isotype: IgG1 kappa
Immunogen: Human breast cancer cell line PMC-42.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from skin, breast or lung carcinoma.
This antibody is designed for the specific localization of human cytokeratin 18 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.