SUMMARY, EXPLANATION AND LIMITATIONS:
Cytokeratin 17 is a Type I cytokeratin with a MW of 46 kD found sometimes in association with Cytokeratin 7. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type Pachyonychia Congenita and Steatocystoma Multiplex. Cytokeratin 17 antibody has been used to distinguish immature Cervical Squamous Metaplasia from high grade Cervical Intraepithelial Neoplasia (CIN III). Anti-CK 17 also labels myoepithelial cells in the benign breast tissue. CK 17 labeling of Breast Carcinoma cells (so-called basal phenotype) has been associated with a poor prognosis.
Isotype: Mouse IgG2b
Immunogen: Keratin preparation from rat enterocytes.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from breast or cervix carcinoma.
This antibody is designed for the specific localization of human Cytokeratin 17 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.