SUMMARY, EXPLANATION AND LIMITATIONS:
Cyclooxygenase (COX-2) is an inducible enzyme involved in production of prostaglandins in inflammatory processes. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX-2 is therefore of interest in studying immuneresponse regulation. COX-2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. There is now increasing evidence that a constitutive expression of COX-2 plays a role in development and progression of malignant epithelial tumors. In studies, COX-2 positivity retained independent roles inpredicting a poor chance of response to treatment. COX-2 positive patients had a shorter overall survival rate than COX-2 negative patients.
Immunogen: A synthetic peptide from C-terminus of rat Cox-2.
Staining pattern: Cytoplasmic and membrane.
Positive control: Tissue sample from lung or colon carcinomas.
This antibody is designed for the specific localization of human COX-2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.