SUMMARY, EXPLANATION AND LIMITATIONS:
Carcinoembryonic antigen (CEA), is synthesized during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. Antibody to CEA is reportedly useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
Immunogen: Human CEA isolated from hepatic metastasis of colon adenocarcinoma.
Staining pattern: Cytoplasmic and luminal membrane.
Positive control: Tissue sample from colon carcinoma or breast carcinoma.
This antibody is designed for the specific localization of human carcinoembryonic antigen using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.