Ref: AP10092 – Clone: 1B12 – Host: Mouse – Method: P – Format: Ready to use

SKU: AP10092 Category: Tag:



CD23 is a 45kDa glycoprotein that acts as a receptor for IgE. It is expressed by interleukin-4 activated B-lymphocytes, by activated macrophages, and by a proportion of follicular dentritic cells. CD23 has been shown to be useful for the differentiation of small lymphocytic lymphomas and mantle cell lymphoma.

Clone: 1B12

Isotype: IgG1

Immunogen: Recombinant external domain of CD23 protein.

Staining pattern: Cell membrane.

Positive control: Tissue sample from tonsil.


This antibody is designed for the specific localization of human CD23 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

CD23 expression was detected in neoplastic lymphoid cells of chronic lymphocytic leukemia B (73-90% of cases), a variable percentage of follicular lymphomas and in a small proportion of large cell lymphomas, in this case and coinciding with the coexpression of CD40 as a way indicative of better prognosis.

Furthermore and although the CD23 molecule is produced by B cells is adsorbed in large quantity on follicular dendritic reticulum cells thus is also used for the identification of their tumors (dendritic reticulum cell sarcoma).