SUMMARY, EXPLANATION AND LIMITATIONS:
CD2 which is also known as E-rosette receptor, T11 and lymphocyte-function antigen-2 (LFA-2)) is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 (LFA-3), and CD15s (Sialyl Lewis X). p56lck, p59fyn, CD3ζ and CD3ε are tyrosine-phosphorylated after CD2 stimulation. CD2 play a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
Immunogen: Recombinant fragment encoding the external domain of the human CD2 protein.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human CD2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
CD2 antigen is an accessory important molecule in mediating the adhesion of activated T cells and thymocytes to antigen presenting cells and target cells. This antibody reacts with the majority of T lymphocytes in peripheral lymphoid tissue, with NK cells, cortical thymocytes and generality of the neoplastic cells of origin T. Amyloid deposits present in Tumours these can exhibit varying levels of positivity in the presence of this antibody.