SUMMARY, EXPLANATION AND LIMITATIONS:
CD15 is present in greater than 90% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is expressed in Reed-Sternberg cells of Hodgkin’s disease (nodular sclerosis, mixed cellularity and lymphocytedepleted subtypes), and on certain types of epithelial cells. It is generally agreed that the Reed-Sternberg cell variants in lymphocyte-predominant Hodgkin’s disease are not reactive with CD15.
Staining pattern: Surface membrane and paranuclear.
Positive control: Tissue sample from Hodgkin´s Lymphoma.
This antibody is designed for the specific localization of human CD15 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.