SUMMARY, EXPLANATION AND LIMITATIONS:
Thrombomodulin (TM) is also known as Fetomodulin (FM), endothelial anticoagulant protein, or glycoprotein P112. Thrombomodulin contains six repeated domains homologous with epidermal growth factor (EGF) and an amino terminal domain homologous to lectin-like protein. Through its accelerated activation of protein C, synthesis of TM is one of several mechanisms important in maintaining thrombo-resistance and thus reducing clot formation on the surface of the endothelial cells. Immunohistochemical staining of formalin-fixed tissue for TM has been used for the study of a variety of vascular tumors, meningiomas and choriocarcinomas.
Immunogen: Recombinant protein encoding the six repeated EGF domains of human thrombomodulin.
Staining pattern: Cell membrane.
Positive control: Tissue sample from mesothelioma, lung or placenta.
This antibody is designed for the specific localization of human CD141 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.