SUMMARY, EXPLANATION AND LIMITATIONS:
CD14 is a 55 kDa protein working as a receptor which binds the complex of lipopolysaccharids (LPS) and LPSbinding protein (LBP). It is mainly expressed on the surface of monocytes and macrophages. The staining of CD14 is especially helpful for the detection of normal and neoplastic cells of the monocytic cell lineage.
This anti-CD14 antibody stains monocytes/macrophages and Langerhans cells in Langerhans cell histiocytosis as well as tumour cells in monocytic leukaemia and histiocytic lymphomas. Additionally, the antibody reacts with diffuse large B-cell lymphomas and splenic marginal zone lymphoma but not with other B-cell lymphomas.
Immunogen: Synthetic peptide corresponding to human CD14 residues.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human CD14 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.