SUMMARY, EXPLANATION AND LIMITATIONS:
CD13 (also known as aminopeptidase-N) is present on most cells of myeloid origin including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also expressed by the majority of AML, CML in myeloid blast crisis, and in a smaller fraction of lymphoid leukemias. CD13 is absent from normal lymphocytes, platelets and erythrocytes. CD13 is also present on fibroblasts, endothelial cells, epithelial cells from renal proximal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells forming bile canaliculi. CD13 plays a role in metabolism of biologically active peptides, in phagocytosis, and in bactericidal/tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV).
Immunogen: Recombinant protein encoding the C-terminal half of the extracellular domain of human CD13.
Staining pattern: Cell membrane.
Positive control: Tissue sample from prostate, liver.
This antibody is designed for the specific localization of human CD13 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.