SUMMARY, EXPLANATION AND LIMITATIONS:
Majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for Ab-1 staining. Weak or no reactivity has been observed with most cell types of normal adult tissue excepting the secretory endometrium. Ab-1 is reportedly useful in distinguishing pulmonary adenocarcinomas (B72.3+) from pleural mesotheliomas (B72.3).
Immunogen: Membrane-enriched fraction of a human breast carcinoma liver metastasis.
Staining pattern: Cell surface and cytoplasmic.
Positive control: Tissue sample from breast or lung carcinoma.
This antibody is designed for the specific localization of human CA 72.4 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.