SUMMARY, EXPLANATION AND LIMITATIONS:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.
Immunogen: A synthetic peptide corresponding to residues near the C terminus of human C1q (subunit A) was used as an immunogen.
Staining pattern: Secreted.
Positive control: Tissue sample from kidney or tonsil.
This antibody is designed for the specific localization of human C1qA using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.