SUMMARY, EXPLANATION AND LIMITATIONS:
C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.
Immunogen: Binds globular head domain of C1q, purified from human plasma.
Staining pattern: Secreted.
Positive control: Tissue sample from kidney tissue from patients with streptococcal glomerulonephritis.
This antibody is designed for the specific localization of human C1q using IHC techniques in frozen tissue sections.