SUMMARY, EXPLANATION AND LIMITATIONS:
BOB-1, also known as B-cell-specific coactivator OBF-1 or OCA-B, is a lymphoid-specific transcriptional coactivator that interacts with the transcription factors Oct-1 and Oct-2. BOB-1 has been shown to be critical for the development of a normal immune response, where it mediates octamer-dependent transcriptional activity in B lymphocytes. It is also critically involved in the formation of germinal centers in secondary lymphoid organs. BOB-1 levels have been observed to be massively upregulated in germinal center B cells, as compared with resting B cells. The BOB-1 antibody labels B lymphocytes and plasma cells. It is expressed in various B cell derived lymphomas and Hodgkin’s lymphomas (HL). The expression of BOB-1 is high in Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), but low in classic HL.
Immunogen: Synthetic peptide from C-terminus of human BOB-1.
Staining pattern: Nuclear.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human BOB-1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.