BOB-1

BOB-1

Ref: AP10045C – Clone: Polyclonal – Host: Rabbit – Method: P,F – Format: Concentrated

SKU: AP10045C Category: Tag:

Description

SUMMARY, EXPLANATION AND LIMITATIONS:

BOB-1, also known as B-cell-specific coactivator OBF-1 or OCA-B, is a lymphoid-specific transcriptional coactivator that interacts with the transcription factors Oct-1 and Oct-2. BOB-1 has been shown to be critical for the development of a normal immune response, where it mediates octamer-dependent transcriptional activity in B lymphocytes. It is also critically involved in the formation of germinal centers in secondary lymphoid organs. BOB-1 levels have been observed to be massively upregulated in germinal center B cells, as compared with resting B cells. The BOB-1 antibody labels B lymphocytes and plasma cells. It is expressed in various B cell derived lymphomas and Hodgkin’s lymphomas (HL). The expression of BOB-1 is high in Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), but low in classic HL.

Polyclonal

Isotype: IgG

Immunogen: Synthetic peptide from C-terminus of human BOB-1.

Staining pattern: Nuclear.

Positive control: Tissue sample from tonsil.

APPLICATIONS:

This antibody is designed for the specific localization of human BOB-1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.