SUMMARY, EXPLANATION AND LIMITATIONS:
This antibody reacts with the alpha isoform of actin from muscle origin, specifically to smooth muscle. It doesn´t show any cross-reactivity with skeletal muscle actin and cardiac muscle as well as other epithelial and mesenchymal cells. Neither reacts with other components of the cytoskeleton.
Immunogen: N-terminal decapeptide of alpha isoform smooth muscle actin, acetylated at the amino-terminus.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from smooth muscle, leiomyoma, leiomyosarcoma or blood vessels.
This antibody is designed for the specific location of the human protein smooth muscle actin by IHC techniques in buffered formalin-fixed tissues and paraffin embedded.
This antibody provides a useful tool for studying the intracellular distribution of actin and its role in the contractile system.