SUMMARY, EXPLANATION AND LIMITATIONS:
Alpha-1-Antichymotrypsin is a glycoprotein found in the alpha (1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily. Alpha-1-Antichymotrypsin antibody reacts with histiocytes and histiocytic neoplasms. Its major application is defining the presence of Alpha-1-Antichymotrypsin in histiocytes and tumors derived from them. In eosinophilic granuloma and malignant histiocytosis, the reaction for this marker is heterogeneous in intensity and distribution. In fibrous histiocytomas, under certain circumstances, a diffuse homogeneous reaction may be observed.
Immunogen: Purified human alpha-1-antichymotrypsin.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from human tonsil.
This antibody is designed for the specific localization of human Alpha-1-Antichymotrypsin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.